Certain individuals should avoid taking Silditop 100 mg (which contains sildenafil citrate) due to potential risks and contraindications. These include: Individuals Taking Nitrates: People using nitrates for chest pain (angina) or heart conditions should avoid sildenafil. Combining these medications can cause a dangerous drop in blood pressure. Those Using Guanylate Cyclase Stimulators: Medications like riociguat, used to treat pulmonary hypertension, can interact adversely with sildenafil. Patients with Severe Cardiovascular Conditions: Those with severe heart or blood vessel conditions, including recent heart attack or stroke, severe heart failure, or uncontrolled hypertension, should avoid sildenafil unless advised by a healthcare provider. Individuals with Severe Liver Impairment: Severe liver disease can affect how Silditop 100mg is metabolized, leading to increased risk of side effects. Those with Severe Kidney Disease: Severe kidney impairment can lead to higher levels of sildenafil in the blood, increasing the risk of side effects. Men Advised Against Sexual Activity: Due to underlying health conditions, some men are advised against engaging in sexual activity, and therefore, should not take ED medications like sildenafil. People with Certain Eye Conditions: Those with a history of non-arteritic anterior ischemic optic neuropathy (NAION) or severe vision loss should avoid sildenafil due to the risk of further vision impairment. Individuals Allergic to Sildenafil: Anyone with a known allergy to sildenafil or any of its components should not take Silditop 100 mg. Women and Children: Sildenafil is not indicated for use in women, especially those who are pregnant or breastfeeding, or in children under 18 years of age. Those Taking Certain Other Medications: Individuals taking medications that affect the enzyme CYP3A4 (such as certain antifungals, antibiotics, and HIV protease inhibitors) should use caution and consult their healthcare provider, as these can interact with sildenafil. It is crucial to consult with a healthcare provider before starting Silditop 100 mg to ensure it is safe and appropriate based on individual health conditions and other medications being taken.